Integrating endocrine-related health effects into comparative human toxicity characterization

Endocrine-disrupting chemicals have the ability to interfere with and alter functions of hormone system, leading adverse effects on reproduction, growth development. Despite growing concerns over their now ubiquitous presence in environment, endocrine-related human health remain largely outside comparative toxicity characterization frameworks as applied for example life cycle impact assessments. In this paper, we propose a new methodological framework consistently integrate into characterization. We present two quantitative operational approaches extrapolating towards common point departure from both vivo dosimetry-adjusted vitro effect data deriving factors well corresponding endocrine-active/endocrine-disrupting chemicals. Following proposed approaches, calculated 323 chemicals, reflecting endocrine potency, related 157 expressing relative potential. Developed are ready use context chemical prioritization substitution assessment other frameworks. Endocrine-related were found comparable existing cancer non-cancer effects, indicating that (1) chemicals' potency is not necessarily higher or lower than potencies (2) using derive does overestimate potential disruptors. Calculated span 8-11 orders magnitude different substances emission compartments dominated by range potencies.